Cancer BiologyRedox BiologyPeer-reviewed
Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia
C. Paiboonrungruang, Z. Xiong, D. Lamson…·X. Chen
This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.
DOI 10.1016/j.redox.2023.102901