Z. Xiong

Mapping fibrotic microenvironments: single-cell and spatial profiling of Schistosoma mansoni-induced tissue fibrosis

This study uses single-cell spatial transcriptomics to map fibrotic microenvironments in Schistosoma mansoni-infected mice, revealing organ-specific fibrosis architecture and shared signaling pairs for potential therapeutic targets.

Bacillus velezensis HBXN2020 alleviates Salmonella Typhimurium infection in mice by improving intestinal barrier integrity and reducing inflammation

This study shows that Bacillus velezensis HBXN2020 reduces Salmonella Typhimurium infection in mice by enhancing intestinal barrier function and decreasing inflammation.

Queen loss fails to elicit physiological and transcriptional responses in workers of the invasive garden ant Lasius neglectus

The paper examines whether queen loss triggers physiological and transcriptional changes in workers of Lasius neglectus, finding no such response, suggesting physiological independence.

Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.

Molecular mechanism of NAD+ binding to the Nudix homology domains of DBC1

This study investigates how NAD+ binds to DBC1's Nudix homology domains using NMR, ITC, and molecular docking, revealing key residues and binding affinity.

In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection

The paper identifies a capsule defect in K. pneumoniae that enhances complement-mediated opsonophagocytosis and persistence during recurrent infections.

Printing double network tough hydrogels using Temperature-Controlled Projection Stereolithography (TOPS)

This paper introduces a method to print double-network hydrogels with superior mechanical properties using temperature-controlled projection stereolithography.

Long-term reliable neural decoding based on flexible implantable microelectronics and machine learning for seizure prediction application

This study combines flexible implantable microelectronics with machine learning to achieve reliable long-term neural decoding for seizure prediction in epileptic mice.

A reductase in the lipid metabolism at cross roads between cuticular wax production and jasmonic acid-mediated defenses in maize

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.

PanGu Drug Model: Learn a Molecule Like a Human

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

Planting graphene quantum dots in PEGylated nanoparticles for enhanced and multimodal in vivo imaging of tumor

This study implants graphene quantum dots in PEGylated nanoparticles to enhance in vivo imaging and tumor detection, showing improved circulation and tumor accumulation.

Dosage-sensitivity shapes how genes transcriptionally respond to allopolyploidy and homoeologous exchange in resynthesized Brassica napus

This study examines how dosage-sensitive genes in Brassica napus respond to homoeologous exchanges and whole-genome duplication, finding constrained expression responses and genomic imbalance.

SUMO E2/E3 Enzyme Co-Recognize Substrates and Confers High Substrates Specificity

The paper develops a high-throughput method to measure protein interaction affinity without purification, applied to SUMO E2/E3 enzymes and substrates, revealing co-recognition and affinity mechanisms.

Convergence of MCR-8.2 and chromosome-mediated resistance to colistin and tigecycline in an NDM-5-producing ST656 Klebsiella pneumoniae from a lung transplant patient

This study reports a pan-drug-resistant Klebsiella pneumoniae isolate carrying NDM-5 and MCR-8.2 genes, along with chromosomal resistance mechanisms to colistin and tigecycline.

Regulation of osteoblast autophagy based on PI3K/AKT/mTOR signaling pathway study on the effect of β-ecdysterone on fracture healing

This study investigates how β-ecdysterone affects fracture healing by modulating autophagy via the PI3K/AKT/mTOR pathway in osteoblasts.

Construction of a neural network energy function for protein physics

This paper develops a neural network energy function for protein physics using unsupervised learning on 3D local structures, showing it can recognize patterns in protein structures.

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

Muscle-specific Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle

This study identifies Cavin4's role in T-tubule formation and stability in skeletal muscle by showing its interaction with Bin1 and effects on caveolae remodeling.

In vivo proteomic mapping through GFP-directed proximity dependent biotin labelling in zebrafish

The paper introduces a method to map protein interactions in zebrafish using GFP-directed biotin labelling and applies it to study caveolin interactors in muscle cells.

Facing small and biased data dilemma in drug discovery with federated learning

This paper applies federated learning to drug discovery, showing it improves prediction accuracy over centralized training with biased and small datasets.

An Endocytic Capture Model for Skeletal Muscle T-tubule Formation

This study develops a four-dimensional model of T-tubule formation in zebrafish using live imaging and electron microscopy, proposing an endocytic capture mechanism involving dynamic endocytic tubules, myofibrils, and membrane delivery from recycling endosomes and Golgi.

Replaying the evolutionary tape to investigate subgenome dominance in allopolyploidBrassica napus

This study investigates subgenome dominance in Brassica napus allopolyploids by replaying the evolutionary tape, finding consistent expression bias towards the C subgenome.

Novel culture method to diagnose fungal infections with biopsy tissues

This paper introduces a novel tissue biopsy culture method that improves fungal detection compared to traditional methods.

CD200 immune checkpoint reversal at the site of tumor vaccine inoculation: A novel approach to glioblastoma immunotherapy

This paper demonstrates that a CD200 peptide inhibitor enhances immune response in glioblastoma by reversing tumor-induced immunosuppression and downregulating PD-1 receptors.