H. Yuan

Estimation of Species Abundance Based on the Number of Segregating Sites using Environmental DNA (eDNA)

The paper estimates species abundance using segregating sites from eDNA, finding a stronger correlation than eDNA concentration.

O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control

The paper identifies O-GlcNAcylation of DDX3X as a regulator of the G1/S-phase transition and shows its role in cell cycle control and neurogenesis in OGT-CDG.

Jianpi Jiedu Recipe inhibits proliferation through reactive oxygen species-induced incomplete autophagy and reduces PD-L1 expression in colon cancer

Insight into the gut virome in patients with multiple sclerosis

This study examines the gut virome in MS patients, finding reduced diversity and specific taxonomic changes compared to healthy controls.

Paternal genomic resources from the YanHuang cohort suggested a Weakly-Differentiated Multi-source Admixture model for the formation of Hans founding ancestral lineages

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

Small Molecule Screen Identifies Pyrimethamine as an Inhibitor of NRF2-driven Esophageal Hyperplasia

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.

High-throughput and in-depth analysis of plasma proteome by UV-assisted protein digestion, 5-plex labeling and MS-based high abundance protein removal method

This study develops a high-throughput plasma proteome analysis workflow using UV-assisted digestion, 5-plex labeling, and MS-based high abundance protein removal to improve quantification of low-abundance proteins.

Alternating Polarity as a Novel Strategy for Cultivating Electro-Methanogenic Microbial Communities Capable of Robust Biogas Production

This paper develops an alternating polarity strategy to cultivate electro-methanogenic microbial communities, resulting in higher biogas production and structurally distinct communities.

Hybrid Modeling of Engineered Biological Systems through Coupling Data-Driven Calibration of Kinetic Parameters with Mechanistic Prediction of System Performance

This paper develops a hybrid modeling strategy that combines data-driven calibration with mechanistic prediction to improve performance prediction of engineered biological systems.

Combination of Polymeric Micelle Formulation of TGFβ Receptor Inhibitors and Paclitaxel Produce Consistent Response Across Different Mouse Models of TNBC

This study combines polymeric micelle-formulated TGFβ receptor inhibitors with Paclitaxel to show consistent anti-tumor effects across multiple TNBC mouse models.

Mammalian Esophageal Stratified Tissue Homeostasis is Maintained Distinctively by the Epithelial Pluripotent p63+Sox2+ and p63-Sox2+ Cell Populations

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.

A stable reference human transcriptome and proteome as a standard for reproducible omics experiments

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

Rapid reversible osmoregulation of cytoplasmic biomolecular condensates of human interferon-α-induced antiviral MxA GTPase

This study shows that MxA GTPase condensates rapidly disassemble and reassemble in response to osmotic changes, maintaining antiviral activity during hypoosmolar conditions.

Synthetic fibrous hydrogels as a platform to decipher cell-matrix mechanical interactions

This study uses synthetic fibrous hydrogels to investigate cell-matrix mechanical interactions and their impact on cellular behavior.

Modulation of the gut microbiome by novel synthetic glycans for the production of propionate and the reduction of cardiometabolic risk factors

This paper identifies a synthetic glycan, KB39, that increases propionate production by the gut microbiome and reduces cardiometabolic risk factors in mice.

The gender gap in academic career achievements and the mediation effect of work-family conflict and partner support

This study examines how parenthood affects gender gaps in academic career achievements, finding that work-family conflict and partner support mediate these gaps.

Double NPY motifs at the N-terminus of Sso2 synergistically bind Sec3 to promote membrane fusion

This study identifies dual-site interactions between Sso2 and Sec3 that drive secretory vesicle fusion in yeast.

Orchestration of Chlorophyll and Carotenoid Biosynthesis by ORANGE Family Proteins in Plant

This study identifies ORANGE family proteins as regulators of chlorophyll and carotenoid biosynthesis in plants, showing their role in coordinating these pathways for photosynthesis and thermotolerance.

Identification and Characterization of Stem Cells in Mammalian Esophageal Stratified Squamous Epithelia

This study identifies and characterizes quiescent stem cells in the mammalian esophageal epithelium using scRNA-seq and DNA methylation profiling in rat models.

An ex vivo culture model of kidney podocyte injury reveals mechanosensitive, synaptopodin-templating, sarcomere-like structures.

The paper develops an ex vivo culture model of kidney podocytes to study injury recovery, revealing mechanosensitive sarcomere-like structures that template synaptopodin.

Bioequivalence Assessment of High-Capacity Polymeric Micelle Nanoformulation of Paclitaxel and Abraxane(R) in Rodent and Non-Human Primate Models Using a Stable Isotope Tracer Assay

Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of leukemia

This study uses sequential CRISPR gene editing in human iPSCs to model clonal evolution in AML, showing progressive dysplasia and identifying therapeutic vulnerabilities.

A contraction-reaction-diffusion model for circular pattern formation in embryogenesis

This study introduces a contraction-reaction-diffusion model that generates circular patterns in embryogenesis by coupling mechanobiological factors with traditional reaction-diffusion equations.

Linking Population Dynamics to Microbial Kinetics for Hybrid Modeling of Engineered Bioprocesses

The paper develops a hybrid modeling strategy integrating microbial population dynamics and data-driven approaches to predict bioprocess outcomes with high accuracy.

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

Nb15-NbH-Nb15, a bispecific nanobody with a heterotrimeric configuration, showed potent neutralization of SARS-CoV-2 in vitro and provided complete protection against infection in hACE2 mice via intranasal administration.

Rapid spread of a symbiotic virus in a major crop pest following wide-scale adoption of Bt-cotton in China

The paper shows that Bt-cotton adoption in China increased the prevalence of a symbiotic virus in the cotton bollworm, enhancing its resistance to Bt-cotton.

Species composition and dynamics of aphids and parasitoid wasps in maize fields in Northeastern China

This study reports the first systematic analysis of aphid and parasitoid wasp species composition and dynamics in maize fields of Jilin Province, China, over two years.

Murine GFP-Mx1 forms phase-separated nuclear condensates and associates with cytoplasmic intermediate filaments: novel antiviral activity against vesicular stomatitis virus

Brassinosteroids Suppress Ethylene Biosynthesis via Transcription Factor BZR1 in Pear and Apple Fruit

BR-activated BZR1 suppresses ACO1 activity and expression of ACO1 and ACS1a, reducing ethylene production during pear and apple fruit ripening.

Quantitative Analysis of Tissue Secretome Reveals the Diagnostic and Prognostic Value of Carbonic Anhydrase II in Hepatocellular Carcinoma

This study uses iTRAQ proteomics to analyze the HCC secretome, identifying CA2 as a diagnostic and prognostic biomarker with potential therapeutic implications.