Author

C. Palles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

I. Tomlinson· 2 shared A. Protheroe· 1 shared A. Ryan· 1 shared C. Loveday· 1 shared C. Turnbull· 1 shared C.-C. Pai· 1 shared D. A. Bell· 1 shared D. Ebner· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

I. Tomlinson

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Expression of the cancer-associated DNA polymerase ϵ P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

I. Soriano, E. Vazquez, N. de Leon, S. Betrand, E. Heitzer, S. Toumazou, C. Palles, C.-C. Pai, T. Humphrey, I. Tomlinson, S. Cotterill, S. Kearsey

This paper models the POLE-P286R mutation in fission yeast, showing it causes hypermutation, DNA replication defects, and dependence on translesion synthesis polymerases.

bioRxiv · Apr 6, 2021Cancer Biology

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

P. Zhang, I. Kitchen-Smith, L. Xiong, G. Stracquadanio, K. Brown, P. Richter, M. Wallace, E. Bond, N. Sahgal, S. Moore, S. Nornes, S. De Val, M. Surakhy, D. Sims, X. Wang, , G. Bond

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

bioRxiv · Nov 9, 2019Cancer Biology