C. Paterson

A BubR1-independent pathway for CENP-E targeting to the outer corona of kinetochores

This study identifies a BubR1-independent, dynein-dependent pathway for CENP-E recruitment to the outer kinetochore corona and shows its role in assembling the corona with RZZ complex and Mad1.

Video-rate remote refocusing through continuous oscillation of a membrane deformable mirror.

This paper demonstrates a deformable mirror system for rapid refocusing in microscopy, achieving video-rate volumetric imaging with high Strehl metrics.

Mathematical Model of Colorectal Cancer Initiation

The paper develops a mathematical model of colorectal cancer initiation, showing that mutation rates and fitness effects determine the order of driver events and that immune suppression may not significantly affect colorectal lesions.

On measuring selection in cancer from subclonal mutation frequencies

The paper develops a stochastic model to analyze subclonal mutation frequencies in cancer, showing that driver mutations are biased towards extreme frequencies and that the 1/f power law may overestimate neutral evolution.

Modulation of corneal tissue mechanics influences epithelial cell phenotype

This study shows that modulating corneal biomechanics can influence limbal epithelial stem cell phenotype in vivo and ex vivo.

An exactly solvable, spatial model of mutation accumulation in cancer

This paper presents an exactly solvable mathematical model of tumour growth and mutation accumulation, showing exponential mutation increase under constant fitness gains and a plateau under decreasing gains.