Human islet expression levels of Prostaglandin E2 synthetic enzymes, but not prostaglandin EP3 receptor, are positively correlated with markers of β-cell function and mass in non-diabetic obesity
N. A. Truchan, R. J. Fenske, H. K. Sandhu, A. M. Weeks, C. Patibandla, B. Wancewicz, S. Pabich, A. Reuter, J. M. Harrington, A. L. Brill, D. C. Peter, R. Nall, M. Daniels, M. Punt, C. E. Kaiser, , M. E. Kimple
The paper examines the relationship between PGE2 production and β-cell function in non-diabetic obesity, finding that PGE2 synthetic enzymes correlate with β-cell mass and function, while EP3 receptor does not.
bioRxiv · Feb 3, 2021Pharmacology & Toxicology