M. J. Campbell

Dual agonism of sodium iodide symporter function in vivo

This study identifies Cu(DDC)2-alb as a dual agonist that enhances RAI uptake in thyroid cancer by stabilizing NIS and inducing thyroid transcription factors.

Epigenetic disruption of the RARγ complex impairs its function to bookmark AR enhancer interactions required for enzalutamide sensitivity in prostate cancer

This study identifies RARγ's role in bookmarking AR enhancer interactions in prostate cancer, showing its impact on enzalutamide sensitivity and lineage plasticity.

Tumor microenvironmental determinants of high-risk DCIS progression

This study identifies immune microenvironment features and myoepithelial continuity as key determinants of progression in high-risk DCIS.

The MYC axis in advanced prostate cancer is impacted through concurrent targeting of ERβ and AR using a novel ERβ-selective ligand alongside Enzalutamide

This study shows that combining a novel ERβ ligand with Enzalutamide reduces MYC signaling and growth in advanced prostate cancer.

ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

Dissecting endocytic mechanisms reveals new molecular targets to enhance sodium iodide symporter activity with clinical relevance to radioiodide therapy

This study identifies an acidic dipeptide in NIS that mediates AP2 binding, showing chloroquine enhances NIS membrane retention and RAI uptake in thyroid cancer.

The major role of sarA in limiting Staphylococcus aureus extracellular protease production is correlated with decreased virulence in diverse clinical isolates in osteomyelitis

This study shows that sarA mutation reduces virulence in S. aureus osteomyelitis by increasing protease production, highlighting its key role in limiting protease output and maintaining virulence.

Vitamin D receptor cistrome-transcriptome analyses establishes quantitatively distinct receptor genomic interactions in African American prostate cancer regulated by BAZ1A

The paper analyzes VDR genomic interactions in African American prostate cancer cells and identifies BAZ1A as a regulator of VDR-dependent transcriptional responses.

Cytoprotective effects of combination of gypenosides and Costus pictus D.Don extract in BRIN-BD11 β-cells

This study investigates the synergistic cytoprotective effects of gypenosides and Costus pictus extract on BRIN-BD11 β-cells against palmitate and cytokine-induced toxicity.

Reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer

This study shows reduced NCOR2 expression accelerates androgen deprivation therapy failure in prostate cancer by promoting DNA hypermethylation and neuroendocrine gene expression.

Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progression

Germline genetic contribution to the immune landscape of cancer

This study identifies germline genetic variants associated with immune traits in cancer, revealing their impact on the tumor immune microenvironment.

Pharmacologically targeting a novel pathway of sodium iodide symporter trafficking to enhance radioiodine uptake

This study identifies ARF4 and VCP as regulators of NIS trafficking and shows FDA-approved VCP inhibitors enhance radioiodine uptake in thyroid cancer cells and mice.

The miR-96 and RAR&gamma signaling axis governs androgen signaling and prostate cancer progression

This study identifies miR-96 as a regulator of RARγ expression, which in turn controls androgen signaling and prostate cancer progression through gene network alterations.