E. Campbell

A SARS-CoV-2 vaccine designed for manufacturability results in unexpected potency and non-waning humoral response

This paper describes a SARS-CoV-2 vaccine, MT-001, that provides durable, broad, and potent immunity without waning or requiring boosting.

Intestinal helminth infection impairs oral and parenteral vaccine efficacy

This study shows that intestinal helminth infection reduces vaccine efficacy by altering immune responses to both oral and parenteral vaccines in mice.

TLR4 regulates proinflammatory intestinal immune responses mediated by an atopic gut microbiota

The paper shows that a CMA-associated gut microbiota enriched in Bacteroidetes and LPS genes promotes proinflammatory responses via TLR4 signaling in infants with cows milk allergy.

Microbial metabolite butyrate-prodrug polymeric micelles demonstrate therapeutic efficacy in pre-clinical models of food allergy and colitis

The paper develops butyrate-prodrug polymeric micelles that restore gut barrier function and reduce inflammation in pre-clinical models of food allergy and colitis.

Functional metagenomic screening in microfluidic droplets identifies a β-glucuronidase in an unprecedented sequence neighbourhood

This study identifies a novel β-glucuronidase from a metagenomic library using microfluidic droplet screening, revealing a new GH3 family member with unique functional and structural properties.

A prion accelerates proliferation at the expense of lifespan

This study shows that the prion [BIG+] in yeast increases proliferation but reduces lifespan by altering protein synthesis and translational programs.

Transcriptomic analysis reveals that severity of infectious bursal disease in White Leghorn inbred chicken lines is associated with greater bursal inflammation in vivo and more rapid induction of pro-inflammatory responses in primary bursal cells stimulated ex vivo.

This study compares the transcriptomic responses of inbred chicken lines to IBDV infection, finding that severe disease correlates with enhanced inflammation and faster pro-inflammatory gene induction in bursal cells.

Effects of gypenosides on enteroendocrine L-cell function and GLP-1 secretion

This study shows gypenosides enhance GLP-1 secretion and antioxidant gene expression in L-cells, suggesting a mechanism for their anti-diabetic effects.

Cargo and Cell Specific Differences in Extracellular Vesicle Populations Identified by Multiplexed Immunofluorescent Analysis

The paper describes a method to analyze extracellular vesicles using multiplexed immunofluorescent imaging, revealing cell and cargo-specific differences in EV populations.

Beyond financial conflicts of interest: Institutional oversight of faculty consulting agreements at schools of medicine and public health

The paper investigates institutional oversight of faculty consulting agreements at U.S. medical and public health schools, finding inconsistent and often weak oversight practices.