High throughput screen in a co-culture model to uncover therapeutic strategies to potentiate the cancer-inhibiting properties of the tumor-stroma in pancreatic cancer
J. E. Mason, J. Cumming, A. U. Eriksson, C. Binder, M. Dongre, C. Patthey, M. Espona-Fiedler, E. Chorell, D. Ohlund
The paper identifies GNF-5 as a compound that inhibits PDAC tumor cell growth by inducing myCAF phenotype in a co-culture model.
bioRxiv · Mar 11, 2022 · PreprintCancer Biology