Perinatal Programming of Mucosal Stromal Cell Identity by the Lymphotoxin Pathway Regulates Mucosal Immune Responses in the Adult
C. Li, E. Lam, C. Perez-Shibayama, D. Lee, L. A. Ward, A. Nguyen, M. Ahmed, K. V. Korneev, O. Rojas, T. Sun, H. H. He, A. Martin, B. Ludewig, J. L. Gommerman
This study shows that in utero Lymphotoxin-beta receptor signaling programs mesenteric lymph node stromal cells to support adult IgA responses by influencing antibody class switch and IgA+ cell generation.
bioRxiv · Feb 21, 2019Immunology