Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons
D. Trono, P. Turelli, C. Playfoot, D. Grun, C. Raclot, J. Pontis, A. Coudray, C. Thorball, J. Duc, E. V. Pankevich, B. Deplancke, V. Busskamp
The paper identifies primate-specific KZFPs that repress retrotransposons in human neurons, influencing differentiation and preventing neurotoxic responses.
bioRxiv · Nov 29, 2019Evolutionary Biology