B. Deplancke

Dissecting reprogramming heterogeneity at single-cell resolution using scTF-seq

The paper introduces scTF-seq, a method to study TF dose-dependent reprogramming in mouse MSCs, revealing heterogeneity in cell fate and TF sensitivity.

Dissection and reconstruction of the colorectal cancer tumor microenvironment

This study reconstructs the colorectal cancer tumor microenvironment using patient-derived organoids and co-cultures, revealing how stromal cells influence cancer behavior and immune evasion.

A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion

The paper identifies an omental-specific stromal population that inhibits adipogenesis via IGFBP2 secretion in human adipose tissue.

Immunofilaments Provide a Nanoscale Platform for In Vivo T Cell Expansion and Cancer Immunotherapy

This paper introduces immunofilaments that expand T cells in vivo, showing efficacy against melanoma when combined with immune checkpoint blockade.

Pseudomonas aeruginosa contracts mucus to form biofilms in tissue-engineered human airways

This study shows Pseudomonas aeruginosa forms mucus-associated biofilms in human airway models by contracting mucus using type IV pili.

Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches

This study creates a spatial proteogenomic atlas of the liver across species, identifying conserved macrophage niches and their regulatory mechanisms.

Postnatal lymph node expansion of stromal progenitors towards reticular and CD34+ stromal cell subsets is determined by distinct transcriptional programs

The paper identifies distinct transcriptional programs driving the expansion of stromal progenitors in mesenteric lymph nodes, revealing Irf3's role in FRC differentiation and microbiota-independent epigenomic signatures.

Mammalian adipogenesis regulators (Aregs) exhibit robust non- and anti-adipogenic properties that arise with age and involve retinoic acid signalling

The paper characterizes CD142+ adipose stem and precursor cells (ASPCs) and shows their non- and anti-adipogenic properties emerge with age via retinoic acid signaling.

Deterministic scRNA-seq of individual intestinal organoids reveals new subtypes and coexisting distinct stem cell pools

The paper introduces DisCo, a deterministic scRNA-seq method for small tissue samples, revealing new intestinal organoid subtypes and stem cell populations.

Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

This study compares temperature-dependent replication and immune response dynamics of SARS-CoV-2 and SARS-CoV in human airway epithelial cells, highlighting differences in their antiviral responses and transmission efficiency.

Genomic analysis of European Drosophila populations reveals major longitudinal structure, continent-wide selection, and unknown DNA viruses

The paper analyzes genomic variation in European Drosophila populations, revealing longitudinal structure, continent-wide selection, and new DNA viruses.

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

The paper identifies primate-specific KZFPs that repress retrotransposons in human neurons, influencing differentiation and preventing neurotoxic responses.

A highly parallel, automated platform enabling individual or sequential ChIP of histone marks and transcription factors

This paper introduces FloChIP, a microfluidic platform for automated ChIP-seq that improves speed, throughput, and sensitivity compared to traditional methods.