P. Turelli

ACE2 mimetic antibody potently neutralizes all SARS-CoV-2 variants and fully protects in XBB.1.5 challenged monkeys

KRAB zinc finger proteins ZNF587/ZNF417 protect lymphoma cells from replicative stress-induced inflammation

This study identifies ZNF587 and ZNF417 as pro-oncogenic factors in DLBCL that reduce replicative stress and inflammation, promoting cancer cell survival and immune evasion.

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

The paper reports cryo-EM structures of mouse ACE2 bound to SARS-CoV-2 VOC Spike proteins, showing mutations enabling immune escape may expand host range.

P2G3 human monoclonal antibody neutralizes SARS-CoV-2 Omicron subvariants including BA.4 and BA.5 and Bebtelovimab escape mutants

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

SARS-CoV-2 Omicron potently neutralized by a novel antibody with unique Spike binding properties

This paper identifies a potent human monoclonal antibody, P2G3, that neutralizes multiple SARS-CoV-2 variants including Omicron, and demonstrates its protective efficacy in a monkey model.

Structural analysis of the Spike of the Omicron SARS-COV-2 variant by cryo-EM and implications for immune evasion.

The paper reports cryo-EM structures of mouse ACE2 bound to Spike proteins of four SARS-CoV-2 variants, revealing mutations that enhance binding and immune evasion.

S-acylation controls SARS-Cov-2 membrane lipid organization and enhances infectivity

The paper shows that S-acylation by ZDHHC20 modifies SARS-CoV-2 membrane proteins, promoting lipid domain formation and enhancing viral infectivity.

Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression

The paper shows HERV activation in tumors upregulates KZFPs, which suppress cancer progression by downregulating cell cycle and adhesion genes, improving disease outcomes.

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

The paper identifies primate-specific KZFPs that repress retrotransposons in human neurons, influencing differentiation and preventing neurotoxic responses.