Heme Attenuates Endogenous Opioid Levels in Leukocytes of HIV positive individuals with Chronic Widespread Pain
S. Aggarwal, J. J. DeBerry, I. Ahmad, L. Prichard, C. R. DeWitte, S. Malik, J. S. Merlin, B. R. Goodin, S. L. Heath, S. Matalon
This study shows that heme-induced ER stress in leukocytes of HIV-positive individuals with chronic widespread pain reduces β-endorphin levels, contributing to increased pain sensitivity.
bioRxiv · Apr 24, 2020Pathology