S. Aggarwal

Skeletal Muscle Mitochondrial Dysfunction Mediated by Pseudomonas aeruginosa Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

This study investigates how Pseudomonas aeruginosa's MvfR quorum sensing transcription factor disrupts mitochondrial function in skeletal muscle and shows that inhibiting MvfR or using mitochondrial-targeted compounds can reverse these effects.

Interferons and tuft cell numbers are bottlenecks for persistent murine norovirus infection

This study uses barcoded viruses to show that IFN-λ and tuft cell numbers limit persistent murine norovirus infection, with distinct viral populations in intestinal and extraintestinal sites.

EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice

This study shows EZH2 deletion in adult acinar cells does not block regeneration but limits PDAC progression by altering the tumor microenvironment and differentiation.

Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination

This study shows that sequential early-life viral infections in mice reduce antibody responses to SARS-CoV-2 vaccination while altering immune cell profiles and gut microbiota.

Scalable early detection of grapevine virus infection with airborne imaging spectroscopy

This paper uses airborne imaging spectroscopy and machine learning to detect GLRaV-3 infection in grapevines during the latent, asymptomatic phase, achieving high accuracy at 3-meter resolution.

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

Erythroid spectrin binding modulates peroxidase and catalase activity of heme proteins

This study shows that spectrin binding modulates peroxidase activity of hemoglobin and other heme proteins, with implications for oxidative damage in diseases like sickle cell disease.

Structural heterogeneity in biliverdin modulates spectral properties of Sandercyanin fluorescent protein

This paper reports the spectral properties and crystal structures of engineered monomeric Sandercyanin-BLA complexes, revealing how structural heterogeneity in biliverdin modulates fluorescence.

Immunological and cardio-vascular pathologies associated with SARS-CoV-2 infection in golden syrian hamster

This study shows that SARS-CoV-2 infection in golden Syrian hamsters causes lung and cardiovascular pathologies similar to human COVID-19, suggesting GSH as a model for studying long-term effects.

Secretome of senescent hepatoma cells modulate macrophage polarization and neutrophil extracellular traps formation

This study shows that senescent hepatoma cells secrete factors that promote M2 macrophage polarization and neutrophil extracellular trap formation, contributing to a tumor-promoting microenvironment.

Site-specific Crosslinking Coupled with Mass Spectrometry as a Structural Tool in Studies of the Human α1 Glycine Receptor

This study uses CX-MS to identify crosslinking sites in the human α1 glycine receptor in its resting state, revealing distance constraints between subunits.

Heme Attenuates Endogenous Opioid Levels in Leukocytes of HIV positive individuals with Chronic Widespread Pain

This study shows that heme-induced ER stress in leukocytes of HIV-positive individuals with chronic widespread pain reduces β-endorphin levels, contributing to increased pain sensitivity.

Heme Impairs Alveolar Epithelial Sodium Channels Post Toxic Gas Inhalation

This study shows that heme impairs alveolar epithelial sodium channels, contributing to pulmonary edema after halogen gas inhalation.

Phosgene Inhalation Causes Hemolysis and Acute Lung Injury

This study investigates the effects of phosgene exposure on mice, showing dose-dependent lung injury and hemolysis, with free heme and membrane breakdown products as potential biomarkers.