C. R. Nisler

This study investigates the evolutionary changes in the cadherin-23 and protocadherin-15 protein complex, showing how sequence variations affect biophysical properties and contribute to deafness-causing mutations across vertebrates.

The paper uses molecular dynamics simulations to study ion conduction in TMC1 models, revealing a peripheral permeation pathway and lipid-mediated gating mechanisms in inner-ear mechanotransduction channels.

This paper uses simulations to study the mechanical responses of different cadherin-based junctions, finding distinct behaviors in adherens junctions and clustered protocadherin junctions under force.

This paper uses molecular dynamics simulations to compare the mechanical responses of classical and clustered cadherin dimers, finding classical cadherins exhibit a two-phased elastic response while clustered protocadherins are brittle and stiffer.

The paper presents the cryo-EM structure of TRPY1, revealing lipid and calcium modulation mechanisms.