R. Araya-Secchi

The prolactin receptor scaffolds Janus kinase 2 via co-structure formation with phosphoinositide-4,5-bisphosphate

This study shows that the prolactin receptor forms a co-structure with JAK2 and PI(4,5)P2, enabling signal transduction by stabilizing the receptor's disordered domain.

Collective Mechanical Responses of Cadherin-Based Adhesive Junctions as Predicted by Simulations

This paper uses simulations to study the mechanical responses of different cadherin-based junctions, finding distinct behaviors in adherens junctions and clustered protocadherin junctions under force.

Elastic versus Brittle Mechanical Responses Predicted for Dimeric Cadherin Complexes

This paper uses molecular dynamics simulations to compare the mechanical responses of classical and clustered cadherin dimers, finding classical cadherins exhibit a two-phased elastic response while clustered protocadherins are brittle and stiffer.

Order and disorder - an integrative structure of the full-length human growth hormone receptor

This study determines the structure of the full-length human growth hormone receptor using integrated SAXS, X-ray diffraction, NMR, and molecular dynamics simulations, revealing a flexible ensemble of domains.

Structural determinants of protocadherin-15 elasticity and function in inner-ear mechanotransduction

This study reports the structure of PCDH15 and its interactions with CDH23, revealing how its ectodomain functions as a gating spring in inner-ear mechanotransduction.

A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15

This study reports the crystal structure of PCDH15's MAD12 domain, showing it induces parallel dimerization and is mechanically weak, with implications for related cadherins.