Author

D. Choudhary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

M. Sotomayor· 3 shared Y. Narui· 3 shared P. De-la-Torre· 2 shared R. Araya-Secchi· 2 shared B. L. Neel· 1 shared C. Chen· 1 shared C. F. Klanseck· 1 shared C. R. Nisler· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

M. Sotomayor

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Environmental feedback drives oxidative stress response heterogeneity in bacterial populations

D. Choudhary, V. Lagage, K. Foster, S. Uphoff

The paper shows that bacterial oxidative stress response heterogeneity arises from deterministic environmental feedback rather than stochastic noise, improving population-level stress tolerance.

bioRxiv · Sep 2, 2022Microbiology

Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation

C. R. Nisler, Y. Narui, D. Choudhary, J. D. Bowman, V. J. Lynch, M. Sotomayor

This study investigates the evolutionary changes in the cadherin-23 and protocadherin-15 protein complex, showing how sequence variations affect biophysical properties and contribute to deafness-causing mutations across vertebrates.

bioRxiv · Jan 23, 2022Evolutionary Biology

Structural determinants of protocadherin-15 elasticity and function in inner-ear mechanotransduction

D. Choudhary, Y. Narui, B. L. Neel, L. N. Wimalasena, C. F. Klanseck, P. De-la-Torre, C. Chen, R. Araya-Secchi, E. Tamilselvan, M. Sotomayor

This study reports the structure of PCDH15 and its interactions with CDH23, revealing how its ectodomain functions as a gating spring in inner-ear mechanotransduction.

bioRxiv · Jul 8, 2019 · PreprintBiophysics

A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15

P. De-la-Torre, D. Choudhary, R. Araya-Secchi, Y. Narui, M. Sotomayor

This study reports the crystal structure of PCDH15's MAD12 domain, showing it induces parallel dimerization and is mechanically weak, with implications for related cadherins.

bioRxiv · Nov 2, 2018Biophysics