Author

C. R. O'Shea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

D. G. Isom· 1 shared G. J. Taghon· 1 shared J. B. Rowe· 1 shared N. J. Kapolka· 1 shared W. M. Morgan· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

D. G. Isom

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Proton-gated coincidence detection is a common feature of GPCR signaling

N. J. Kapolka, J. B. Rowe, G. J. Taghon, W. M. Morgan, C. R. O'Shea, D. G. Isom

The paper shows that many GPCRs use proton binding to modulate signaling, affecting ligand efficacy, potency, cooperativity, antagonism, and constitutive activity, with ADORA2A as a new acid sensor.

bioRxiv · Jan 8, 2021Pharmacology & Toxicology