Author

N. J. Kapolka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

D. G. Isom· 2 shared G. J. Taghon· 2 shared J. B. Rowe· 2 shared W. M. Morgan· 2 shared C. R. O'Shea· 1 shared J. F. Enten· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 14 mutual co-author links

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2 shared papersPharmacology & Toxicology

D. G. Isom

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2 papers

Recent·Most cited

Proton-gated coincidence detection is a common feature of GPCR signaling

N. J. Kapolka, J. B. Rowe, G. J. Taghon, W. M. Morgan, C. R. O'Shea, D. G. Isom

The paper shows that many GPCRs use proton binding to modulate signaling, affecting ligand efficacy, potency, cooperativity, antagonism, and constitutive activity, with ADORA2A as a new acid sensor.

bioRxiv · Jan 8, 2021Pharmacology & Toxicology

DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery

N. J. Kapolka, G. J. Taghon, J. B. Rowe, W. M. Morgan, J. F. Enten, D. G. Isom

DCyFIR enables high-throughput CRISPR-based profiling of GPCRs and ligand discovery by integrating receptors into yeast genomes and analyzing ligand specificity across multiple strains.

bioRxiv · Jan 16, 2020Pharmacology & Toxicology