Author

D. G. Isom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

G. J. Taghon· 2 shared J. B. Rowe· 2 shared N. J. Kapolka· 2 shared W. M. Morgan· 2 shared A. A. Bobkov· 1 shared A. Hoang· 1 shared C. D. Sohl· 1 shared C. R. O'Shea· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPharmacology & Toxicology

G. J. Taghon

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Compartment-Specific Activation of the Proton-Sensor GPR65 is Uncoupled from Receptor Trafficking

L. M. Morales Rodriguez, S. E. Crilly, J. Rowe, D. G. Isom, M. A. Puthenveedu

This study shows that GPR65, a proton-sensor GPCR, is constitutively active in endosomes and its signaling is uncoupled from receptor trafficking.

bioRxiv · Mar 18, 2023 · PreprintPharmacology & Toxicology

Proton-gated coincidence detection is a common feature of GPCR signaling

N. J. Kapolka, J. B. Rowe, G. J. Taghon, W. M. Morgan, C. R. O'Shea, D. G. Isom

The paper shows that many GPCRs use proton binding to modulate signaling, affecting ligand efficacy, potency, cooperativity, antagonism, and constitutive activity, with ADORA2A as a new acid sensor.

bioRxiv · Jan 8, 2021Pharmacology & Toxicology

An acidic residue buried in the dimer interface of isocitrate dehydrogenase 1 (IDH1) helps regulate catalysis and pH sensitivity

L. A. Luna, Z. Lesecq, K. A. White, A. Hoang, D. A. Scott, O. Zagnitko, A. A. Bobkov, D. L. Barber, J. M. Schiffer, D. G. Isom, C. D. Sohl

This paper identifies an acidic residue in IDH1 that regulates catalysis and pH sensitivity through conformational changes.

bioRxiv · Apr 19, 2020Biochemistry

DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery

N. J. Kapolka, G. J. Taghon, J. B. Rowe, W. M. Morgan, J. F. Enten, D. G. Isom

DCyFIR enables high-throughput CRISPR-based profiling of GPCRs and ligand discovery by integrating receptors into yeast genomes and analyzing ligand specificity across multiple strains.

bioRxiv · Jan 16, 2020Pharmacology & Toxicology