Longitudinal Proteomic Profiling of T Cell Differentiation In Vivo Reveals Biochemical Remodeling Underlying Exhaustion
C. M. Beusch, A. S. Dawood, A. Ozdilek, S. Welbourn, C. M. Monaco, A. S. Flegle, S. Malik, C. Niavi, A. Akhtar, C. Roman, A. A. Gavora, D. E. Gordon, M. S. Abdel-Hakeem
This study profiles longitudinal proteomic and phosphoproteomic changes in CD8 T cells during acute and chronic infections, identifying exhaustion-associated proteins and phosphosites with potential therapeutic relevance.
bioRxiv · May 14, 2024 · PreprintImmunology