Author

A. M. de Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 6 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:virus· 2 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

A. J. Markmann· 2 shared L. Premkumar· 2 shared R. S. Baric· 2 shared S. Graham· 2 shared A. Brackbill· 1 shared A. Burgos· 1 shared A. C. P. Ana C. Puhl· 1 shared A. Grinyo· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

A. J. Markmann

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Author profile →

6 papers

Recent·Most cited

CD4+ T Cell Depletion Before Primary Dengue and/or Secondary Zika Infection Reveals Mechanistic Correlates of Antibody Functionality in Rhesus Macaques.

C. Serrano-Collazo, A. M. Miranda, L. A. Cruz, S. Henein, M. R. Sanchez-Rosado, L. Alvarez, T. Arana, M. I. Martinez, C. Roman, A. Burgos, A. M. de Silva, C. A. Sariol

This study shows that CD4+ T cell depletion before DENV infection affects antibody specificity and cross-reactivity during subsequent ZIKV infection in rhesus macaques.

bioRxiv · Feb 22, 2024 · PreprintImmunology

A semi-quantitative, rapid, point of care SARS-CoV-2 serologic assay predicts neutralizing antibody levels

A. J. Markmann, D. R. Bhowmik, B. Jiang, M. Van Hoy, F. Wang, Y. J. Hou, R. S. Baric, A. M. de Silva, L. A. Bartelt

This paper introduces a semi-quantitative lateral flow assay that correlates with neutralizing antibody levels in SARS-CoV-2 recovered individuals.

bioRxiv · May 30, 2023 · PreprintImmunology

Structure and Neutralization Mechanism of a Human Antibody Targeting a Complex Epitope on Zika Virus

C. Adams, D. L. Carbaugh, B. Sho, T.-S. Ng, I. Castillo, R. Bhowmik, B. Segovia-Chumbez, A. C. P. Ana C. Puhl, S. Graham, s. diehl, H. Lazear, A. M. de Silva, S.-m. Lok, L. Premkumar

This study defines the epitope and neutralization mechanism of a human antibody targeting Zika virus by showing that cross-linking of viral envelope proteins is critical for neutralization.

bioRxiv · Aug 22, 2022Microbiology

SARS-CoV-2 mRNA Vaccine Induces Robust Specific and Cross-reactive IgG and Unequal Strain-specific Neutralizing Antibodies in Naïve and Previously Infected Recipients

T. M. Narowski, K. Raphel, L. E. Adams, J. Huang, N. A. Vielot, R. Jadi, A. M. de Silva, R. S. Baric, J. E. Lafleur, L. Premkumar

This study examines antibody responses to SARS-CoV-2 mRNA vaccines in naive and previously infected individuals, finding robust IgG and varying neutralizing antibody levels against different variants.

bioRxiv · Jun 19, 2021Immunology

A novel antigenic site spanning domains I and III of the Zika virus envelope glycoprotein is the target of strongly neutralizing human monoclonal antibodies

S. Graham, H. A. Tu, B. D. McElvany, N. R. Graham, A. Grinyo, E. Davidson, B. J. Doranz, S. A. Diehl, A. M. de Silva, A. J. Markmann

This study identifies a novel antigenic site on the Zika virus envelope glycoprotein targeted by a strongly neutralizing human monoclonal antibody, providing insights for vaccine design.

bioRxiv · Dec 21, 2020Immunology

Oligomeric state of the ZIKV E protein defines protective immune responses.

S. W. Metz, A. Thomas, A. Brackbill, J. Forsberg, M. J. Miley, C. A. Lopez, H. M. Lazear, S. Tian, A. M. de Silva

This study shows that dimeric Zika E protein antigens induce stronger neutralizing antibodies than monomers, suggesting that mimicking viral quaternary structure improves subunit vaccine efficacy.

bioRxiv · Jun 18, 2019Microbiology