Mapping Cellular Response to Destabilized Transthyretin Reveals Cell- and Amyloidogenic Protein-Specific Signatures
S. Ghosh, C. Villacorta-Martin, J. Lindstrom-Vautrin, D. Kenney, C. S. Golden, C. V. Edwards, V. Sanchorawala, L. H. Connors, R. M. Giadone, G. J. Murphy
The paper exposes cells to destabilized TTR variants and analyzes transcriptional and epigenetic responses to identify cell- and protein-specific signatures of amyloidogenic stress.
bioRxiv · Aug 17, 2022Cell Biology