Author

R. M. Giadone

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

G. J. Murphy· 3 shared S. Ghosh· 3 shared C. V. Edwards· 2 shared L. H. Connors· 2 shared V. Sanchorawala· 2 shared A. A. Wilson· 1 shared A. Ordureau· 1 shared A. Staron· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

G. J. Murphy

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Author profile →

4 papers

Recent·Most cited

Abnormal global longitudinal strain and reduced serum inflammatory markers in cardiac AL amyloidosis patients without significant amyloid fibril deposition

C. V. Edwards, G. M. Ferri, J. Villegas-Galaviz, S. Ghosh, P. Singh Bawa, F. Wang, E. Klimtchuk, T. B. Ajayi, G. J. Morgan, T. Prokaeva, A. Staron, F. L. Ruberg, V. Sanchorawala, R. M. Giadone, G. J. Murphy

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

bioRxiv · Mar 14, 2024Cell Biology

Analyzing ER stress response in ALS patient derived motor neurons identifies druggable neuroprotective targets

M. E. Watts, R. M. Giadone, A. Ordureau, K. M. Holton, J. W. Harper, L. L. Rubin

The paper uses ER stressors in ALS patient-derived motor neurons to identify druggable targets that protect against degeneration.

bioRxiv · Nov 16, 2023Cell Biology

Mapping Cellular Response to Destabilized Transthyretin Reveals Cell- and Amyloidogenic Protein-Specific Signatures

S. Ghosh, C. Villacorta-Martin, J. Lindstrom-Vautrin, D. Kenney, C. S. Golden, C. V. Edwards, V. Sanchorawala, L. H. Connors, R. M. Giadone, G. J. Murphy

The paper exposes cells to destabilized TTR variants and analyzes transcriptional and epigenetic responses to identify cell- and protein-specific signatures of amyloidogenic stress.

bioRxiv · Aug 17, 2022Cell Biology

Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

R. M. Giadone, D. C. Liberti, T. M. Matte, J. D. Rosarda, C. Torres-Arancivia, S. Ghosh, J. K. Diedrich, S. Pankow, N. Skvir, J.-C. Jean, J. R. Yates, A. A. Wilson, L. H. Connors, D. N. Kotton, R. L. Wiseman, G. J. Murphy

This study uses iPSC-derived hepatic cells to show that liver proteostasis factors and UPR signaling correlate with TTR amyloid production and can reduce amyloid secretion through ER stress-independent activation.

bioRxiv · Nov 10, 2019 · PreprintCell Biology