Author

L. H. Connors

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

G. J. Murphy· 2 shared R. M. Giadone· 2 shared S. Ghosh· 2 shared A. A. Wilson· 1 shared C. S. Golden· 1 shared C. Torres-Arancivia· 1 shared C. V. Edwards· 1 shared C. Villacorta-Martin· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

G. J. Murphy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Role of Complementarity-Determining Regions 1 and 3 in Pathologic Amyloid Formation by Human Immunoglobulin κ1 Light Chains

E. S. Klimtchuk, D. Peterle, E. A. Bullitt, L. H. Connors, J. R. Engen, O. Gursky

This study investigates how mutations in CDR1 and CDR3 regions of human immunoglobulin κ1 light chains influence amyloid formation through structural and dynamic analyses.

bioRxiv · Feb 1, 2023Biochemistry

Mapping Cellular Response to Destabilized Transthyretin Reveals Cell- and Amyloidogenic Protein-Specific Signatures

S. Ghosh, C. Villacorta-Martin, J. Lindstrom-Vautrin, D. Kenney, C. S. Golden, C. V. Edwards, V. Sanchorawala, L. H. Connors, R. M. Giadone, G. J. Murphy

The paper exposes cells to destabilized TTR variants and analyzes transcriptional and epigenetic responses to identify cell- and protein-specific signatures of amyloidogenic stress.

bioRxiv · Aug 17, 2022Cell Biology

Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

R. M. Giadone, D. C. Liberti, T. M. Matte, J. D. Rosarda, C. Torres-Arancivia, S. Ghosh, J. K. Diedrich, S. Pankow, N. Skvir, J.-C. Jean, J. R. Yates, A. A. Wilson, L. H. Connors, D. N. Kotton, R. L. Wiseman, G. J. Murphy

This study uses iPSC-derived hepatic cells to show that liver proteostasis factors and UPR signaling correlate with TTR amyloid production and can reduce amyloid secretion through ER stress-independent activation.

bioRxiv · Nov 10, 2019 · PreprintCell Biology