Microglia and perivascular macrophages act as antigen presenting cells to promote CD8 T cell infiltration of the brain
E. N. Goddery, C. E. Fain, C. G. Lipovsky, K. Ayasoufi, L. T. Yokanovich, C. S. Malo, R. H. Khadka, Z. P. Tritz, F. Jin, M. J. Hansen, A. J. Johnson
This study identifies microglia and perivascular macrophages as antigen-presenting cells that present MHC class I antigens to CD8 T cells, facilitating their infiltration into the brain during viral infection.
bioRxiv · Apr 9, 2021Immunology