Author

R. H. Khadka

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

A. J. Johnson· 4 shared C. E. Fain· 4 shared F. Jin· 4 shared K. Ayasoufi· 4 shared L. T. Yokanovich· 4 shared M. J. Hansen· 4 shared Z. P. Tritz· 4 shared E. N. Goddery· 3 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersImmunology

A. J. Johnson

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4 papers

Recent·Most cited

Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS injury and viral infection

K. Ayasoufi, D. M. Wolf, S. L. Namen, Z. P. Tritz, F. Jin, C. K. Pfaller, E. N. Goddery, C. E. Fain, L. R. Gulbicki, R. H. Khadka, L. T. Yokanovich, M. J. Hansen, A. J. Johnson

This study identifies antigen-specific brain-resident memory T cells that expand rapidly after CNS injury or viral infection and induce neuroinflammation and peripheral immune suppression.

Brain, Behavior, and Immunity · Aug 1, 2023Peer-reviewedImmunology

Microglia and perivascular macrophages act as antigen presenting cells to promote CD8 T cell infiltration of the brain

E. N. Goddery, C. E. Fain, C. G. Lipovsky, K. Ayasoufi, L. T. Yokanovich, C. S. Malo, R. H. Khadka, Z. P. Tritz, F. Jin, M. J. Hansen, A. J. Johnson

This study identifies microglia and perivascular macrophages as antigen-presenting cells that present MHC class I antigens to CD8 T cells, facilitating their infiltration into the brain during viral infection.

bioRxiv · Apr 9, 2021Immunology

Severe and multifaceted systemic immunosuppression caused by experimental cancers of the central nervous system requires release of non-steroid soluble mediators

K. Ayasoufi, C. K. Pfaller, L. Evgin, R. H. Khadka, Z. P. Tritz, E. N. Goddery, C. E. Fain, L. T. Yokanovich, B. T. Himes, F. Jin, J. Zheng, M. R. Schuelke, M. J. Hansen, W. Tung, L. R. Pease, , A. J. Johnson

This study identifies non-steroid soluble factors released by CNS cancers and injuries that cause systemic immunosuppression by inducing thymic and splenic involution and reducing MHC class II expression.

bioRxiv · Mar 24, 2020 · PreprintImmunology

Conditional silencing of H-2Db class I molecule expression on dendritic cells modulates the protective and pathogenic kinetics of virus-antigen specific CD8 T cell responses during Theiler’s Virus infection

Z. P. Tritz, R. C. Orozco, C. S. Malo, L. T. Yokanovich, K. Ayasoufi, C. E. Fain, R. H. Khadka, M. L. Settell, M. J. Hansen, F. Jin, A. J. Johnson

This study shows that CD11c+ antigen-presenting cells are critical for early CD8 T cell responses against TMEV, but not for later responses, using a conditional H-2Db knockout mouse model.

bioRxiv · May 9, 2019Immunology