Author

R. C. Orozco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

K. Marquardt· 2 shared K. Mowen· 2 shared L. A. Sherman· 2 shared A. Domissy· 1 shared A. J. Johnson· 1 shared A. R. Fehr· 1 shared C. E. Fain· 1 shared C. M. Kerr· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

K. Marquardt

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4 papers

Recent·Most cited

Autoimmunity associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity

R. C. Orozco, K. Marquardt, I. Pratumchai, K. Mowen, A. Domissy, J. R. Teijaro, L. A. Sherman

The study shows that the PTPN22 1858C>T allele, linked to autoimmunity, enhances anti-viral immunity by improving CD4 T cell responses and CD8-cDC function during LCMV infection.

bioRxiv · Jun 28, 2023 · PreprintImmunology

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

C. M. Kerr, S. Parthasarathy, N. Schwarting, J. J. O'Connor, E. Giri, S. More, R. C. Orozco, A. R. Fehr

This paper shows PARP12 inhibits replication of a Mac1 mutant coronavirus in some cell and tissue types but not all, suggesting other PARPs also contribute to antiviral defense.

bioRxiv · Jun 16, 2023 · PreprintMicrobiology

Pro-autoimmune allele of tyrosine phosphatase, PTPN22, enhances tumor immunity

R. C. Orozco, K. Marquardt, K. Mowen, L. A. Sherman

This study shows that a pro-autoimmune allele of PTPN22 enhances anti-tumor immunity by increasing immune cell infiltration and reducing immunosuppressive cells in tumors.

bioRxiv · Mar 17, 2021Immunology

Conditional silencing of H-2Db class I molecule expression on dendritic cells modulates the protective and pathogenic kinetics of virus-antigen specific CD8 T cell responses during Theiler’s Virus infection

Z. P. Tritz, R. C. Orozco, C. S. Malo, L. T. Yokanovich, K. Ayasoufi, C. E. Fain, R. H. Khadka, M. L. Settell, M. J. Hansen, F. Jin, A. J. Johnson

This study shows that CD11c+ antigen-presenting cells are critical for early CD8 T cell responses against TMEV, but not for later responses, using a conditional H-2Db knockout mouse model.

bioRxiv · May 9, 2019Immunology