Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation
C. Salaun, H. Takizawa, A. Galindo, K. R. Munro, J. McLellan, I. Sugimoto, T. Okino, N. C. O. Tomkinson, L. H. Chamberlain
This study develops a FRET-based high-throughput screen to identify inhibitors of zDHHC2 auto-acylation, discovering two tetrazole compounds that inhibit both auto-acylation and substrate S-acylation.
bioRxiv · Mar 17, 2022Cell Biology