Author

L. H. Chamberlain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

N. C. O. Tomkinson· 3 shared C. Salaun· 2 shared J. Greaves· 2 shared A. Galindo· 1 shared H. J. Spence· 1 shared H. Takizawa· 1 shared I. Sugimoto· 1 shared J. Batista· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

N. C. O. Tomkinson

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3 papers

Recent·Most cited

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation

C. Salaun, H. Takizawa, A. Galindo, K. R. Munro, J. McLellan, I. Sugimoto, T. Okino, N. C. O. Tomkinson, L. H. Chamberlain

This study develops a FRET-based high-throughput screen to identify inhibitors of zDHHC2 auto-acylation, discovering two tetrazole compounds that inhibit both auto-acylation and substrate S-acylation.

bioRxiv · Mar 17, 2022Cell Biology

The Linker Domain of SNAP25 Acts as a Flexible Molecular Spacer to Ensure Efficient S-Acylation

C. Salaun, J. Greaves, N. C. O. Tomkinson, L. H. Chamberlain

This study shows that the flexible linker in SNAP25 ensures efficient S-acylation by coupling enzyme-substrate interaction with the acylation process.

bioRxiv · Jan 21, 2020Cell Biology

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

L. Fort, J. Batista, P. A. Thomason, H. J. Spence, J. Greaves, K. J. Martin, K. I. Anderson, P. Brown, S. Lilla, M. P. Neilson, P. Tafelmeyer, S. Zanivan, S. Ismail, N. C. O. Tomkinson, L. H. Chamberlain, , L. M. Machesky

This study identifies CYRI proteins as local inhibitors of Scar/WAVE-induced lamellipodia that bind to active Rac1, regulating protrusion size and complexity.

bioRxiv · Nov 29, 2017Cell Biology