H. Takizawa

Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis

This study shows that Mto1 dysfunction disrupts mitochondrial translation, leading to iron overload and defective erythroid differentiation.

Development of a novel high-throughput screen for the identification of new inhibitors of protein S-acylation

This study develops a FRET-based high-throughput screen to identify inhibitors of zDHHC2 auto-acylation, discovering two tetrazole compounds that inhibit both auto-acylation and substrate S-acylation.

Akkermansia Muciniphila induces chronic extramedullary hematopoiesis through cooperative IL-1R and TLR signals

This study shows that Akkermansia muciniphila induces chronic extramedullary hematopoiesis through cooperation between IL-1R and TLR signals in a mouse model.

Hematopoietic stem and progenitor cells integrate Bacteroides-derived innate immune signals to promote gut tissue repair

This study shows that Bacteroides activates HSPCs in the BM during acute gut inflammation to promote tissue repair, but impairs HSC function in chronic inflammation and aging.

Quantitative and molecular differences distinguish adult human medullary and extramedullary haematopoietic stem and progenitor cell landscapes

This study compares HSPC landscapes in bone marrow, spleen, and peripheral blood using single-cell RNA-seq, revealing distinct molecular and functional differences in haematopoiesis across these sites.