Charcot-Leyden Crystals activate the NLRP3 inflammasome and cause IL-1β inflammation
J. F. Rodrigues-Alcazar, M. A. Ataide, G. Engels, C. Schmitt-Mabmunyo, N. Garbi, W. Kastenmueller, E. Latz, B. S. Franklin
This study shows that Charcot-Leyden crystals activate the NLRP3 inflammasome, leading to IL-1β release and inflammation in vitro and in vivo.
bioRxiv · Jan 25, 2018Immunology