Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
J. R. Thomas, K. M. Moore, C. Sproat, H. Maldonado, S. Mo, S. Haider, D. E. Hammond, G. J. Thomas, I. A. Prior, P. R. Cutillas, L. J. Jones, J. F. Marshall, M. R. Morgan
This study shows that Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and drives breast cancer invasion by coordinating matrix stiffness and transcriptional reprogramming.
bioRxiv · Sep 4, 2018 · PreprintCancer Biology