Author

J. R. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 5 Assay:proteomics· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:statistical model· 2 Organism:zebrafish· 2

Frequent Co-Authors

M. Schirle· 3 shared C. C. Ward· 2 shared D. K. Nomura· 2 shared J. A. Tallarico· 2 shared J. M. McKenna· 2 shared M. M. Gottesman· 2 shared R. W. Robey· 2 shared S. M. Brittain· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

M. Schirle

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and their Zebrafish Homologs at the Blood-Brain Barrier

C. T. Inglut, J. A. Quinlan, R. W. Robey, J. R. Thomas, J. R. Walker, W. Zhou, H.-C. Huang, M. M. Gottesman

The paper identifies NanoLuciferase substrates transported by human and zebrafish ABC transporters at the BBB, aiding in the development of a transgenic zebrafish model to detect BBB disruptors.

bioRxiv · Oct 20, 2023 · PreprintPharmacology & Toxicology

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier

J. R. Thomas, W. J. E. Frye, R. W. Robey, A. C. Warner, D. Butcher, J. L. Matta, T. C. Morgan, E. F. Edmondson, P. B. Salazar, S. Ambudkar, M. M. Gottesman

The paper identifies Abcg2a as the functional homolog of human ABCG2 at the zebrafish blood-brain barrier, showing its substrate overlap and BBB localization.

bioRxiv · May 18, 2023Cell Biology

Human HLFneg placental erythro-myeloid progenitors give rise to HLA Class IIneg Hofbauer cells

J. R. Thomas, A. Appios, E. F. Calderbank, X. X. Zhao, R. S. Hamilton, A. Moffett, A. Sharkey, E. Laurenti, N. McGovern

The paper identifies placental erythro-myeloid progenitors (PEMPs) that generate Hofbauer cells, showing human primitive haematopoiesis occurs in the placenta, not just the yolk sac.

bioRxiv · Feb 26, 2022 · PreprintImmunology

Chemoproteomics Enabled Discovery of Selective Probes for NuA4 Factor BRD8

D. Remillard, N. A. Savage, A. T. Kedves, J. Paulk, X. Chen, F. J. Garcia, M. J. Romanowski, P. A. Horton, J. Murphy, M. Schirle, E. M. Harrington, M. B. Maxwell, H. T. Pham, I. Maksimovic, J. R. Thomas, W. C. Forrester

The paper identifies a novel interaction between BRD8 and the NuA4 complex using chemoproteomics and develops selective probes for BRD8.

bioRxiv · Feb 22, 2021Biochemistry

Is Palmer's elm leaf goldenrod real? The Angiosperms353 kit provides within-species signal in Solidago ulmifolia s.l.

J. B. Beck, M. L. Markley, M. G. Zielke, J. R. Thomas, H. J. Hale, L. D. Williams, M. G. Johnson

The paper evaluates the taxonomic status of Solidago ulmifolia var. palmeri using morphological and phylogenomic analyses, finding no support for its distinct status and suggesting its name be discarded.

bioRxiv · Jan 7, 2021 · PreprintEvolutionary Biology

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

J. N. Spradlin, X. Hu, C. C. Ward, S. M. Brittain, M. D. Jones, L. Ou, M. To, A. Proudfoot, E. Ornleas, M. Woldegiorgis, J. A. Olzmann, D. E. Bussiere, J. R. Thomas, J. A. Tallarico, J. M. McKenna, , D. K. Nomura

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

bioRxiv · Apr 9, 2019Cancer Biology

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

C. C. Ward, J. I. Kleinman, S. M. Brittain, P. S. Lee, C. Y. S. Chung, K. Kim, Y. Petri, J. R. Thomas, J. A. Tallarico, J. M. McKenna, M. Schirle, D. K. Nomura

This study identifies a covalent ligand for RNF4, an E3 ligase, and demonstrates its use in designing a bifunctional degrader that effectively degrades BRD4.

bioRxiv · Nov 16, 2018Biochemistry