Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
R. M. Giadone, D. C. Liberti, T. M. Matte, J. D. Rosarda, C. Torres-Arancivia, S. Ghosh, J. K. Diedrich, S. Pankow, N. Skvir, J.-C. Jean, J. R. Yates, A. A. Wilson, L. H. Connors, D. N. Kotton, R. L. Wiseman, G. J. Murphy
This study uses iPSC-derived hepatic cells to show that liver proteostasis factors and UPR signaling correlate with TTR amyloid production and can reduce amyloid secretion through ER stress-independent activation.
bioRxiv · Nov 10, 2019 · PreprintCell Biology