J. K. Diedrich

Diverse competitor B cell responses to a germline-targeting priming immunogen in human Ig loci transgenic mice

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

Evolving spike-protein N-glycosylation in SARS-CoV-2 variants

This study compares N-glycan processing in SARS-CoV-2 spike-proteins across variants to understand immune evasion mechanisms.

Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

Heat shock chaperone HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition

This study shows HSPB1 regulates cytoplasmic TDP-43 phase separation and liquid-to-gel transition, with implications for neurodegenerative diseases like ALS.

DeGlyPHER: an ultrasensitive method for analysis of viral spike N-glycoforms

DeGlyPHER is an ultrasensitive method to analyze viral spike N-glycoforms, assessing glycan occupancy and processing from high-mannose to complex forms at each N-glycosylation site.

Visualization of the HIV-1 Env Glycan Shield Across Scales

This study uses cryo-EM, computational modeling, and mass-spectrometry to analyze the HIV-1 Env glycan shield's structure and dynamics, revealing how heterogeneity and interactions affect epitope accessibility and trimer stability.

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

The paper uses cryo-EM and glycan analysis to study the structure of a full-length SARS-CoV-2 spike protein in a vaccine candidate, revealing its stable prefusion conformation and novel trimer interactions.

Covalent Protein Painting Reveals Structural Changes in the Proteome in Alzheimer Disease

The paper introduces CPP, a method to quantify lysine accessibility in proteins, and finds altered lysine accessibility in Alzheimer's disease patients.

Amyloidogenic Proteins Drive Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease

This study uses iPSC-derived hepatic cells to show that liver proteostasis factors and UPR signaling correlate with TTR amyloid production and can reduce amyloid secretion through ER stress-independent activation.

A non-acidic method using hydroxyapatite and phosphohistidine monoclonal antibodies allows enrichment of phosphopeptides containing non-conventional phosphorylations for mass spectrometry analysis.

This paper introduces a non-acidic method using hydroxyapatite and phosphohistidine antibodies to enrich non-conventional phosphopeptides for mass spectrometry analysis, detecting 425 unique phosphorylation sites.

A Systems Mechanism for KRAS Mutant Allele Specific Responses to Targeted Therapy

The paper investigates why KRAS G13D mutant colorectal cancers respond to anti-EGFR therapy despite general resistance, using computational models and experimental validation.