Hybrid histidine kinase activation by cyclic di-GMP- mediated domain liberation
B. N. Dubey, E. Agustoni, R. Boehm, A. Kaczmarczyk, F. Mangia, C. von Arx, U. Jenal, S. Hiller, I. Plaza-Menacho, T. Schirmer
This study reveals how c-di-GMP regulates ShkA, a hybrid histidine kinase in Caulobacter crescentus, by inducing domain dissociation and allosteric activation.
bioRxiv · Jun 22, 2019Biochemistry