Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein
Y.-S. Huang, C.-H. Fan, N. Hsu, C.-Y. Wu, C.-Y. Chang, S.-R. Hong, Y.-C. Chang, A. Y.-T. Wu, V. Guo, Y.-C. Chiang, W.-C. Hsu, N.-H. Chiu, L. Chen, C. P.-K. Lai, C.-K. Yeh, Y. C. LIN
This paper introduces a sonogenetic method using an engineered auditory-sensing protein to control cellular activities with ultrasound, showing it can stimulate neurons in deep brain regions non-invasively.
bioRxiv · May 3, 2019Bioengineering