SARS-CoV-2 ORF6 disturbs nucleocytoplasmic trafficking to advance the viral replication
Y. Miyamoto, Y. Itoh, T. Suzuki, T. Tanaka, Y. Sakai, M. Koido, C. Hata, C.-X. Wan, M. Otani, K. Moriishi, T. Tachibana, Y. Kamatani, Y. Yoneda, T. Okamoto, M. Oka
This study shows SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking by inhibiting STAT1 nuclear translocation and binding importin 1, enhancing viral replication, particularly in older individuals.
bioRxiv · Feb 24, 2021 · PreprintMicrobiology