Y. Miyamoto

Importin α Characterizes a Micronuclear Environment Associated with Genomic Instability in Human Cancer Cells

The paper identifies importin α as a marker of a distinct micronuclear environment in cancer cells, associated with genomic instability and immune evasion.

Importin-7-dependent nuclear localization of the Flavivirus core protein is required for infectious virus production.

This study identifies importin-7 as a nuclear carrier for Flaviviridae core proteins and shows its requirement for infectious virus production.

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors

This study determines the cryo-EM structures of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors, revealing their binding modes and explaining inhibitor specificity.

Development of subunit selective substrates for Trichomonas vaginalis proteasome

The paper develops three subunit-specific fluorogenic substrates for the T. vaginalis proteasome and identifies effective inhibitor targets.

Phase-separated nuclear bodies of nucleoporin fusions, SET-NUP214 and NUP98-HOXA9, promote condensation of MLL1 and CRM1 to activate target genes

This study shows that nucleoporin fusions form phase-separated nuclear bodies that enhance gene activation by condensing MLL1 and CRM1 at target loci.

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.

This study develops a stable SARS-CoV-2 replicon system for high-throughput antiviral screening under BSL2 conditions, demonstrating its utility with remdesivir and interferon-β.

A stress-reduced passaging technique improves the viability of human pluripotent cells

This paper introduces a stress-reduced passaging technique for human pluripotent stem cells that improves viability and downstream application efficiency without altering cell characteristics.

Hematopoietic stem and progenitor cells integrate Bacteroides-derived innate immune signals to promote gut tissue repair

This study shows that Bacteroides activates HSPCs in the BM during acute gut inflammation to promote tissue repair, but impairs HSC function in chronic inflammation and aging.

SARS-CoV-2 ORF6 disturbs nucleocytoplasmic trafficking to advance the viral replication

This study shows SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking by inhibiting STAT1 nuclear translocation and binding importin 1, enhancing viral replication, particularly in older individuals.

Relationship between ocean area and incidence of anthropogenic debris ingested by longnose lancetfish (Alepisaurus ferox)

This study examines plastic ingestion in longnose lancetfish across different ocean areas, finding higher incidence in Sagami Bay compared to the North Pacific and Indian Ocean.