T. Tanaka

Identification of new resistance QTL regions in loquat cultivar Champagne against Pseudomonas syringae pv. eriobotryae group C

This study identifies a novel QTL region on LG14 associated with resistance to loquat canker group C in the Champagne cultivar.

cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens.

The paper reports the cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens and develops mutants with blue-shifted action spectra.

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonism

The paper reports cryo-EM structures of the ETB receptor bound to the lasso peptide RES-701-3, revealing its inverse agonist mechanism through hydrophobic interactions and conformational stabilization.

Can Colpoda travel across oceans? Salinity tolerance of resting cysts may enable global dispersal of the species.

The study investigates whether Colpoda cucullus resting cysts can tolerate saline conditions, suggesting a mechanism for oceanic dispersal of freshwater protists.

Analysis of chronic host-aspergilloma interactions using a novel mouse model

This paper develops a novel mouse model of aspergilloma to study host-fungal interactions, revealing Th1/Th17 responses and angiogenesis induced by dead fungal hyphae.

HOIL-1L deficiency induces cell cycle alteration which causes immaturity of myocyte and fibrogenesis

This study shows HOIL-1L deficiency leads to cell cycle defects and fibrosis in myotubes and cardiomyocytes, contributing to myopathy and dilated cardiomyopathy.

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

Engineering a highly durable adeno-associated virus receptor for analytical applications

The paper engineers a durable AAV receptor for analyzing AAV-AAVR interactions, showing diverse binding affinities among AAV serotypes and enabling quality checks and purification of AAV vectors.

Sprouty4 is required for Mdm2 regulation of invasion, focal adhesion formation and metastasis in cells lacking p53.

The paper shows that Mdm2 and MdmX regulate cell migration, invasion, and metastasis through Sprouty4 in p53-deficient cells.

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in RAS-mutated chronic myelomonocytic leukemia

This study identifies MCL1 as a survival factor in RAS-mutated CMML, explaining resistance to BCL2 inhibitors and suggesting new therapeutic targets.

Structural basis for lysophosphatidylserine recognition by GPR34

This study presents cryo-EM structures of GPR34-Gi complex bound with LysoPS analogs, revealing ligand recognition mechanisms and identifying 2-acyl LysoPS as the physiological ligand.

RNA processing/modifying enzymes play key roles in the response to thermospermine in Arabidopsis thaliana

The paper identifies four genes involved in RNA processing and modification that modulate thermospermine's effect on xylem differentiation in Arabidopsis.

Mapping Protein Dynamics at High-Resolution with Temperature-Jump X-ray Crystallography

This study uses temperature-jump X-ray crystallography to observe atomic-scale protein motions in lysozyme, showing how vibrations evolve into functional movements and how inhibitors alter these dynamics.

Extension of bacterial rDNA sequencing to concurrent epigenetic analysis and its application to 16S meta-epigenetics

This paper introduces an add-on method to 16S rDNA sequencing for concurrent DNA methylation analysis, identifying novel methylation sites and a methyltransferase in Morganella morganii.

The role of rice SOG1 and SOG1-like in DNA damage response

The paper identifies OsSOG1 as a key regulator of DNA damage response and repair in rice, showing its role through phosphorylation and gene regulation, while OsSGL has a limited role.

Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.

This study develops a stable SARS-CoV-2 replicon system for high-throughput antiviral screening under BSL2 conditions, demonstrating its utility with remdesivir and interferon-β.

Severe fever with thrombocytopenia syndrome virus and parthenogenetic Asian longhorned tick Haemaphysalis longicornis (Acari: Ixodidae)

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation

This study identifies that CDC42 C-terminal variants cause aberrant Golgi localization, leading to pyrin inflammasome activation and autoinflammation.

CCN2 activates ERK-signaling via integrin αv and enhances the interaction of ERK and DUSP6 in lymphatic endothelial cells

This study shows CCN2 promotes lymphangiogenesis by activating ERK signaling through integrin αv and enhancing ERK-DUSP6 interaction in lymphatic endothelial cells.

Satelight: Self-Attention-Based Model for Epileptic Spike Detection from Multi-Electrode EEG

Satelight detects epileptic spikes in EEG using self-attention, achieving high accuracy with fewer parameters than existing models.

Clomipramine suppresses ACE2-mediated SARS-CoV-2 entry

This study shows clomipramine inhibits SARS-CoV-2 entry into cardiomyocytes and synergizes with remdesivir to suppress infection.

SARS-CoV-2 ORF6 disturbs nucleocytoplasmic trafficking to advance the viral replication

This study shows SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking by inhibiting STAT1 nuclear translocation and binding importin 1, enhancing viral replication, particularly in older individuals.

Dermal macrophages set pain sensitivity by modulating tissue NGF levels through SNX25-Nrf2 signaling

The paper identifies SNX25 in dermal macrophages as a regulator of NGF levels through Nrf2 signaling, affecting pain sensitivity in mice.

Anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) potency of Mefloquine as an entry inhibitor in vitro

This study identifies Mefloquine as a potent in vitro entry inhibitor of SARS-CoV-2 with higher antiviral activity than Hydroxychloroquine.

Plasma irradiation efficiently inactivates the coronaviruses mouse hepatitis virus and SARS-CoV-2

This study tests plasma discharge as a method to inactivate SARS-CoV-2 and MHV, finding high viral inactivation rates after 1-3 hours of treatment.

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

The paper identifies leukemia stemness and co-occurring mutations as drivers of resistance to IDH inhibitors in AML through genomic analyses of treated patients.

High-resolution Crystal Structures of Transient Intermediates in the Phytochrome Photocycle

The paper captures high-resolution crystal structures of transient phytochrome intermediates to elucidate the structural changes during the Pr-to-Pfr photocycle.

Structural basis for no spectral shift of heliorhodopsin by counterion mutation

The paper presents the crystal structure of a HeR mutant with an identical absorption spectrum to wild-type, revealing a unique spectral shift mechanism through counterion and serine cluster interactions.

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

This study identifies a new multidrug combination treatment for COVID-19 using nelfinavir and cepharanthine, showing synergistic antiviral effects and improved disease control.

Multiband entropy-based feature-extraction method for automatic identification of epileptic focus based on high- frequency components in interictal iEEG

This paper develops a machine learning method using entropy features from high-frequency iEEG subbands to accurately identify epileptic focus in patients.