Sensory neuronal mTORC1 signaling establishes neuroimmune memory that initiates allergic immunity
Xueping Zhu, Haibo Yang, Haoting Zhan, Isabela Kernin, Ngoc Le, Dean R Buttaci, Cai Han, Parth R. Naik, Lukas M. Altenburger, Elena Wu, Peri R. Matatia, Sarah Zaghouani, Neal Patrick Smith, Rebecca Londoner, Cameron H. Flayer, , Caroline L. Sokol
The paper identifies a sensory neuron-intrinsic mTORC1 signaling mechanism that establishes neuroimmune memory, enhancing allergic immunity upon allergen re-exposure.
bioRxiv · Nov 10, 2025 · PreprintImmunology