Lukas M. Altenburger

Chemokine Landscapes of the Tumor Microenvironment

The paper maps chemokine landscapes in solid tumors using spatial transcriptomics, identifying conserved and tumor-specific patterns and revealing perivascular CCR7 dendritic cells as key sources of lymphocyte-attracting chemokines.

Type 2 conventional dendritic cells and regulatory T cells form a barrier tissue circuit to control allergic inflammation

The paper identifies a cDC2-Treg feedback circuit in barrier tissues that limits Th2 cell expansion during allergic inflammation.

A lymphoid tissue chemokine checkpoint prevents loss of CD8+ T cell functionality

This study identifies a lymphoid tissue chemokine checkpoint that regulates CD8+ T cell release from dendritic cells, preventing loss of effector function.

Antibody peptide epitope conjugates for αPD-1 therapy-resistant head and neck squamous cell carcinoma

This study develops antibody-peptide epitope conjugates (APECs) to enhance anti-tumor activity in ICB-resistant HNSCC by leveraging viral peptide-loaded MHC I proteins and protease activity.

Sensory neuronal mTORC1 signaling establishes neuroimmune memory that initiates allergic immunity

The paper identifies a sensory neuron-intrinsic mTORC1 signaling mechanism that establishes neuroimmune memory, enhancing allergic immunity upon allergen re-exposure.