Genetic reduction of the translational repressors FMRP and 4E-BP2 preserves memory in mouse models of Alzheimer's disease
Felipe Campos Ribeiro, Danielle Cozachenco, Michael Parkhill, Brandon Rodrigue, Caio Borges, Jean‐Claude Lacaille, Karim Nader, Fernanda G. De Felice, Mychael V. Lourenco, Argel Aguilar‐Valles, Nahum Sonenberg, Sergio Teixeira Ferreira
This study shows that reducing FMRP and 4E-BP2 in mice prevents memory loss caused by Alzheimer's disease-linked amyloid-beta oligomers.
Aging Cell · Dec 3, 2025Peer-reviewedNeuroscience