Jean‐Claude Lacaille

This study shows that reducing FMRP and 4E-BP2 in mice prevents memory loss caused by Alzheimer's disease-linked amyloid-beta oligomers.

This study identifies two distinct astrocyte subtypes in the hippocampus that selectively regulate inhibitory synapses in specific domains through functional and transcriptional differences.

The paper shows that mTORC1 in hippocampal somatostatin interneurons is essential for learning reward-related spatial representations during a virtual reality task.

This study shows that both GEF domains of the Trio protein are essential for proper tangential migration of GABAergic interneurons, with GEFD2 playing a dominant role.

This study shows that lysosomal storage diseases cause synaptic structure and neurotransmission defects before cognitive symptoms appear in mice and humans.

This study shows that mTORC1 activity in somatostatin interneurons regulates hippocampal memory by modulating synaptic plasticity and fear memory consolidation.