Karim Nader

This study shows that reducing FMRP and 4E-BP2 in mice prevents memory loss caused by Alzheimer's disease-linked amyloid-beta oligomers.

The paper investigates how mild and strong fear memories differ in brain connectivity, finding that strong memories disrupt network connectivity and isolate the amygdala.

The paper investigates how PKMζ levels change during memory destabilization and reconsolidation, showing transient reduction followed by renewal, and identifies NMDA receptor activation as necessary for memory vulnerability to PKMζ-antisense.

The paper shows that activation of the noradrenaline-locus coeruleus system during strong fear memory encoding increases stability in the amygdala, making memories resistant to reconsolidation.