Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau
Anastasie Maté de Gérando, Lindsay A. Welikovitch, Anita Khasnavis, Caitlin Commins, Calina A. Glynn, Joshua E Chun, Romain Perbet, Bradley T. Hyman
The paper compares the bioactivity of fibrillar and oligomeric tau forms in Alzheimer's disease, finding HMW tau more potent in glial activation and tau propagation.
Acta Neuropathologica · Jun 21, 2023Peer-reviewedNeuroscience