Rare bioactive tau oligomers from Alzheimer brain support both templated misfolding and fibril formation
Noé Quittot, Dhanush Sivasankaran, Dorothea Böken, Yu Chen, Joshua E Chun, Anne E. Wiedmer, Victoria Derosla, M Martins, Forest A Brooks, Georg Meisl, Matthew W. Cotton, Durga G Arumuganainar, Theresa R. Connors, Alexandra N. Melloni, Matthew P. Frosch, , Bradley T. Hyman
The paper identifies rare bioactive tau oligomers in Alzheimer's brain that can induce templated misfolding and fibril formation, distinguishing them from non-bioactive oligomers.
bioRxiv · Sep 24, 2025 · PreprintNeuroscience