Author

Caitlin Herrington

University of British Columbia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alessandro CauiD· 1 shared Ana P. Niciforovic· 1 shared Barry P. YoungiD· 1 shared Catharine H. RankiniD· 1 shared Christopher J. R. LoeweniD· 1 shared Daniel B. Callaghan· 1 shared Douglas W. AllaniD· 1 shared Fabian MeiliiD· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Alessandro CauORCID

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1 paper

Recent·Most cited

Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction

Kathryn L. Post, Manuel Belmadani, Payel Ganguly, Fabian Meili, Riki Dingwall, Troy A. McDiarmid, Warren M. Meyers, Caitlin Herrington, Barry P. Young, Daniel B. Callaghan, Sanja Rogić, Matthew Edwards, Ana P. Niciforovic, Alessandro Cau, Catharine H. Rankin, , Kurt Z. Haas

The paper evaluates 106 PTEN variants using 18 assays across 5 models to identify molecular mechanisms of dysfunction, finding that stability and domain-specific assays are critical for accurate impact assessment.

Nature Communications · Apr 29, 2020Peer-reviewedGenetics